https://unilib.phaidrabg.rs/o:7490 ISBN: 978-86-7520-629-3 BENEFICIAL IMPACTS OF CHOKEBERRY AND TART CHERRY BASED DIETARY SUPPLEMENTS IN DIABETICS 2025 Diabetes mellitus (DM) is a metabolic disorder that may cause increased risk of various diseases mostly cardiovascular ones. Currently, available therapies are effective for some individuals, but not all. As a result, there is a high need for novel antidiabetic medications or treatments which can help to regulate glycemia or reduce the negative consequences of diabetes, especially on blood vessels. Epidemiological studies have shown that diet can significantly affect blood sugar levels, and berries rich in polyphenols, especially anthocyanins, have shown particularly good effects. Concerning the chemical composition of chokeberry (Aronia melanocarpa), it has been highlighted that anthocyanins are the most important pharmacologically active compounds responsible for its antioxidative, anti-inflammatory, and vasoprotective effects. More recently, the promising potential of cherry juice, originated from tart cherry (Prunus cerasus), a low-calorie fruit rich in secondary metabolites such as anthocyanins, hydoxycinnamates, and flavan-3-ols, in terms of its antioxidant (stimulation of superoxide dismutase and glutathione peroxidase) and anti-inflammatory properties (inhibition of cyclooxygenase-2) was revealed Our aim was to evaluate the effect of combined oral consumption of two dietary supplements based on chokeberry and tart cherry juices over a period of 90 days on HbA1C and, systolic and diastolic pressure, intimo-medial complex (IMC) where atherosclerosis takes place and safety in 27 volunteers with diabetes type 2. Moreover, in vitro antidiabetic activity of juices and supplements were studied. Statistically significant decrease in the thickness of both, carotid and femoral artery was noticed. Slight decrease in systolic and diastolic pressure was observed but it was not statistically significant while an improvement in HbA1C was observed in 62% of respondents. Moreover, the levels of creatinine, urea, ALT and AST values remained within normal limits, which indicates that the products did not have negative effects on the liver and kidneys during the study pointed its safety. In vitro inhibition of both, alpha-glucosidase and alpha-amylase was noticed for chokeberry and tart cherry juices as well as for both dietary supplements (IC50 0.11 ± 0.02, 21.77 ± 1.66, 0.06 ± 0.01, 0.08 ± 0.01, 5.13 ± 0.11, 12.51 ± 0.83, 6.89 ± 0.36, 9.28 ± 0.04 mg/mL, respectively). BOOK OF ABSTRACTS startpage: 32 endpage: 33 eng chokeberry, tart cherry, dietary supplements, diabetes info:eu-repo/semantics/conferenceProceedings application/pdf 1190914 bytes Šavikin, Katarina Živković, Jelena Krgović, Nemanja Bigović, Dubravka All rights reserved