o:6957 Cyclodextrin-aided green extraction from Fagopyrum esculentum Moench – an effective strategy for the sustainable recovery of polyphenols en As a rich source of polyphenolic compounds, Fagopyrum esculentum Moench herb, is a valuable subject for a numerous industries, such as pharmaceutical, chemical, food, or cosmetic. Given the biological potential that is closely related to the polyphenolic content, this study aimed to develop ecologically suitable cyclodextrin-aided extraction from the aerial parts of F. esculentum. To maximize the polyphenolic content, highly-reliable mathematical and statistical method – response surface methodology (RSM) was used for the evaluation of crucial extraction parameters: temperature, extraction time, concentrations of ethanol and two types of cyclodextrins (β-cyclodextrin (β-CD), and (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD)). While temperature and ethanol concentration significantly influenced the total phenolic content (TPC) in both models, the impact of cyclodextrin concentration was observed when HP-β-CD was used. According to the RSM analysis, optimal conditions for the maximization of TPC were noted for the extraction at 80 °C for 40 min, using 50% ethanol and 1.50% HP-β-CD. Thus, under optimized extraction conditions, the measured TPC was 42.1562 ± 1.0101 mg GAE/g DW, among rutin was the most abundant with content of 29.5479 mg/g DW, followed by the quercetin and quercitrin in slightly scarcer content. This study confirmed that cyclodextrin-aided extraction is an ecologically friendly, effective method for the recovery of F. esculentum polyphenolics. common buckwheat; ultrasound-assisted extraction; cyclodextrin; extraction optimization; response surface methodology; rutin 1552099 10.61652/leksir2444012K 1552101 0455-6224 2025-01-28T12:14:17.413Z 44 no 46 Snežana Kuzmanović Nedeljković Institute for Medicinal Plant Research ''Dr. Josif Pančić'' Belgrade 0000-0003-4989-8758 46 Milica Radan Institute for Medicinal Plants Research "Dr Josif Pančić" Belgrade 0000-0002-6727-7624 46 Dubravka Bigović Institute for Medicinal Plants Research "Dr Josif Pančić" Belgrade 0000-0003-1999-2743 46 Katarina Šavikin Institute for Medicinal Plant Research, ''Dr. Josif Pančić'' Belgrade 0000-0002-2086-9593 application/pdf 1125272 https://unilib.phaidrabg.rs/o:6957 no yes 1 70 92000004 71A10 Lekovite sirovine Natural Medicinal Materials Institut "Dr Josif Pančić" Beograd 2024