Melissa officinalis, ethnobotany, medicinal plants, therapeutic effects, traditional medicine, traditional knowledge 2024 Traditional Ethnobotanical Applications of Melissa officinalis for Niš district https://unilib.phaidrabg.rs/o:6934 doi:10.46793/ChemN7.1.27SJ info:eu-repo/semantics/article Stankov Jovanović, Vesna Stepić, Katarina Jovanović, Tijana Ćirić, Slobodan Ljupković, Radomir Ickovski, Jovana Marković, Marija All rights reserved Chemia Naissensis volume: 7 number: 1 startpage: 27 endpage: 35 eng application/pdf 299007 bytes ABSTRACT Melissa officinalis (lemon balm) has been utilized for centuries in traditional medicine for its diverse therapeutic properties. This study explores its traditional applications and evaluates the pharmacological evidence supporting its use in treating various ailments. The bioactive compounds present in M. officinalis, such as rosmarinic acid, flavonoids, and essential oils, are responsible for its notable effects, including anxiolytic, antimicrobial, antioxidant, and digestive benefits. Traditional uses of M. officinalis in Niš District, southeastern Serbia, spanning from alleviating stress, anxiety and sleep problems to treating gastrointestinal discomfort, align with findings from contemporary scientific research. Despite its extensive history of use and integration in modern medicinal therapeutic practices, further clinical investigations are needed to substantiate its safety, efficacy, and mechanisms of action. This paper highlights the significance of M. officinalis as a bridge between traditional knowledge and modern medicinal applications, as well as the importance of preserving traditional knowledge.