o:5865 In Vitro Anti-Helicobacter pylori Activity of Berberine and Barberry Extracts: A Preliminary Report en Abstract The berberine accumulation in Berberis vulgaris and antibacterial activity of plant extracts against Helicobacter pylori were examined. The antibacterial activities of berberine, the main alkaloid of B. vulgaris, and standard antimicrobials metronidazole and tetracycline were also determined. Berberine content was investigated using high-performance liquid chromatography. The antibacterial activity of plant extracts, berberine and reference antibiotics was tested by the broth microdilution method. The highest amount of berberine was found in the root bark (3.99 g/kg, dry wt). The plant extracts tested exhibited in vitro antibacterial activity against H. pylori, but the activities were lower than those of berberine. Keywords HPLC, berberine, Berberis vulgaris, Helicobacter pylori, antibacterial activity 1552099 10.1177/1934578X19857905 1552101 1555-9475 2024-10-29T09:59:44.438Z 44 yes 46 Branislava D. Kocić 46 Marija V. Dimitrijević 46 Ljiljana C. Miladinović 46 Marija S. Marković 0000-0002-6070-6844 46 Goran Ž. Ranković 46 Dragoljub L. Miladinović application/pdf 214648 https://unilib.phaidrabg.rs/o:5865 no yes 16 70 92000001 2019 71A07 Natural Product Communications 1 3 Sage Publications Inc 2019