Keywords HPLC, berberine, Berberis vulgaris, Helicobacter pylori, antibacterial activity http://creativecommons.org/licenses/by/4.0/legalcode info:eu-repo/semantics/article In Vitro Anti-Helicobacter pylori Activity of Berberine and Barberry Extracts: A Preliminary Report Natural Product Communications startpage: 1 endpage: 3 application/pdf 214648 bytes https://unilib.phaidrabg.rs/o:5865 doi:10.1177/1934578X19857905 ISSN: 1555-9475 2019 Abstract The berberine accumulation in Berberis vulgaris and antibacterial activity of plant extracts against Helicobacter pylori were examined. The antibacterial activities of berberine, the main alkaloid of B. vulgaris, and standard antimicrobials metronidazole and tetracycline were also determined. Berberine content was investigated using high-performance liquid chromatography. The antibacterial activity of plant extracts, berberine and reference antibiotics was tested by the broth microdilution method. The highest amount of berberine was found in the root bark (3.99 g/kg, dry wt). The plant extracts tested exhibited in vitro antibacterial activity against H. pylori, but the activities were lower than those of berberine. Kocić, Branislava D. Dimitrijević, Marija V. Miladinović, Ljiljana C. Marković, Marija S. Ranković, Goran Ž. Miladinović, Dragoljub L. eng Sage Publications Inc