o:496 Application potential of biogenically synthesized silver nanoparticles using Lythrum salicaria L. extracts as pharmaceuticals and catalysts for organic pollutant degradation en This study was designed to evaluate the optimal conditions for the eco-friendly synthesis of silver nanoparticles (AgNPs) using Lythrum salicaria L. (Lythraceae) aqueous extracts and their potential application and safe use. AgNPs synthesized using L. salicaria aerial parts (LSA-AgNPs) and root extract (LSR-AgNPs) were characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM/EDS), and X-ray powder diffraction (XRPD). Dynamic light scattering (DLS) was used for the determination of the size distribution profiles of the obtained nanoparticles. Both L. salicaria extracts showed high phenolic content, while the flavone C-glucosides orientin, vitexin, and isovitexin were detected in extracts using HPLC. The synthesized AgNPs displayed growth inhibition of the tested bacteria and fungi in concentrations between 0.156 and 1.25 mg mL 1. The studied nanoparticles also showed antioxidant potential and gained selectivity at different concentrations on different cancer cell lines. Concentrations of LSA-AgNPs were found to be 20.5 and 12 mg mL 1 towards A431 and SVT2, respectively, while LSR-AgNPs were effective only against A431 cancer cells (62 mg mL 1). The hemolytic activity of LSA-AgNPs in concentrations up to 150 mg mL 1 was not observed, while LSR-AgNPs in the highest applied concentration hemolyzed 2.8% of erythrocytes. The degradation possibility of Congo red and 4-nitrophenol using LSA-AgNPs and LSR-AgNPs as catalysts was also proven. The results indicate that L. salicaria may be used for the eco-friendly synthesis of AgNPs with possible applications as antimicrobial and selective cytotoxic agents towards cancer cell lines, as well as in catalytic degradation of pollutants. 1552099 10.1039/d1ra05570d 91552100 65961993 2022-06-29T10:11:49.911Z 44 yes 46 Nikola Srećković Univerzitet u Kragujevcu, Prirodno-matematički fakultet, Departman za hemiju ; University of Kragujevac, Faculty of Science, Department of Chemistry 0000-0002-0216-5816 Zoran Nedić Univerziet u Beogradu, Fakultet za fizičku hemiju ; University of Belgrade, Faculty of Physical Chemistry person Davide Liberti cUniversity of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Department of Chemical Sciences person Daria Marija Monti University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Department of Chemical Sciences person Nevena Mihailović Univerzitet u Kragujevcu, Prirodno-matematički fakultet, Departman za hemiju ; University of Kragujevac, Faculty of Science, Department of Chemistry person Jelena Katanić Stanković Univerzitet u Kragujevcu, Institut za informacione tehnologije, dUniversity of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science person 0000-0002-2997-9588 Silvana Dimitrijević Institut za rudarstvo i metalurgiju Bor ; Mining and metallurgy Institute Bor person Vladimir Mihailović Univerzitet u Kragujevcu, Prirodno-matematički fakultet, Departman za hemiju ; University of Kragujevac, Faculty of Science, Department of Chemistry person 0000-0003-4113-6804 application/pdf 1362506 https://unilib.phaidrabg.rs/o:496 no yes 16 https://v2.sherpa.ac.uk/id/publication/25266?template=romeo 70 92000001 71A03 RSC advances. - ISSN 2046-2069 11 35585 35599 2021