o:3225 Joint surgical associations (EACTS, LACES, ASCVTS, AATS, and STS) position statement regarding the VARC-3 definitions for aortic valve clinical research en Conducting optimal clinical research is complex, resource intensive, and time consuming. A critical part of improving the evidence to guide our cardiovascular clinical practice is clinical trials’ methodologic design and choices of outcomes and endpoints. The Academic Research Consortia were created to define the most critical and standardized definitions of outcome measures. The Valve Academic Research Consortium (VARC) has substantially improved the quality of trials on aortic valve interventions through its multiple iterations. The latest VARC-3 definitions1 aim to add more granularity and a patient focus to a rapidly evolving field and are particularly useful in providing a standard definition of bioprosthetic valve failure. This position statement considers the strengths and limitations of the VARC-3 document, identifies areas of concern, and proposes a way forward to further improve these definitions. Key words: VARC-3, definitions, rehospitalization, thrombus 91552100 128787209 1552101 1552-6259 1552099 10.1016/j.athoracsur.2021.12.004 2023-11-14T20:07:42.145Z 44 yes 46 Patrick Myers 106347273 2022 46 Victor Dayan 2022 46 Wilson Y. Szeto 46 Vinod H. Thourani 46 S. Chris Malaisrie 46 Marc R. Moon 46 Richard L. Prager 46 Minoru Ono 46 Yutaka Okita 46 Nicholas Freemantle 46 Milan Milojević 106163721 0000-0003-0984-9011 application/pdf 95126 https://unilib.phaidrabg.rs/o:3225 no yes 1 70 616.126.5-089 92000001 71A11 The annals of thoracic surgery 113 6 1767 1769 2022