o:2952 Lifestyle changes and medical therapy in slowing the growth of small abdominal aortic aneurysms Promene načina života i medikamentna terapija u usporavanju rasta malih aneurizmi abdominalne aorte en SUMMARY: The goal of our review was to evaluate the impact of lifestyle changes and medical therapy in slowing the growth of small abdominal aortic aneurysms (AAA), as well as to introduce current ideas for future treatment. No viable evidence was found that medical therapy can slow the growth of small AAAs. The beneficial role of propranolol, angiotensin-converting enzyme inhibitors and doxycycline in reducing the growth rate of AAA was ruled out by randomized controlled studies, whereas the efficiency of statins, macrolides and anti-platelet therapy remains controversial. On the other hand, smoking cessation is the only established lifestyle change that was effective in impeding the AAA expansion. Also, there are a considerable number of novel therapeutic strategies related to the problem, which still need to be evaluated in clinical trials, including administration of Cyclosporine A, gene therapy and mesenchymal stem cell treatment. SAŽETAK: Cilj našeg rada je bio da ispitamo uticaj promena načina života i medikamentne terapije na usporavanje rasta aneurizmi abdominalne aorte (AAA) i da ukažemo na aktuelne ideje za budući tretman. Nismo pronašli zadovoljavajuće dokaze da medikamentna terapije može da uspori rast malih AAA. Randomizovane kontrolisane studije su opovrgle povoljnu uloga propranolola, inhibitora angiotenzin-konvertujućeg enzima i doksiciklina u smanjenju rasta AAA, dok je efikasnost statina, makrolida i anti-trombocitnih lekova i dalje sporna. Sa druge strane, prestanak pušenja je jedina promena u načinu života koja se pokazala efikasnom u usporavanju rasta AAA. Takodje, značajnom broju novih terapeutskih strategija za usporavanje rasta AAA predstoje klinička ispitivanja, uključujući primenu ciklosporina A, genetsku terapiju i lokalnu primenu mezenhimalnih matičnih ćelija. Key words: abdominal aortic aneurysm, medical therapy, lifestyle changes, growth Ključne reči: aneurizma abdominalne aorte, medikamentna terapija, način života, rast 91552100 126148361 1552101 0301-0619 2023-10-12T09:23:25.056Z 44 yes 46 Mihailo Nešković 29988455 0000-0003-4829-985X 2016 46 Nenad, Đukić 29990247 2016 46 Slobodan Tanasković 19201127 0000-0003-4216-6693 2016 46 Srđan Babić 19073383 0000-0001-9659-9190 2016 46 Predrag Matić 19191399 0000-0002-9043-347X 2016 46 Dragoslav Nenezić 12441703 0000-0002-2608-4535 2016 46 Predrag Gajin 19182183 0000-0001-9707-8805 2016 46 Đorđe Radak 12465767 0000-0003-3199-5613 2016 application/pdf 96442 https://unilib.phaidrabg.rs/o:2952 no yes 16 Podatak o licenci prema https://scindeks.ceon.rs/journaldetails.aspx?issn=0301-0619 70 616.13‑007.64 92000001 71A11 Medicinska istraživanja 50 1 10 13 2016