Medicinska istraživanja 50(1) Nešković, Mihailo Đukić, Nenad, Tanasković, Slobodan Babić, Srđan Matić, Predrag Nenezić, Dragoslav Gajin, Predrag Radak, Đorđe Lifestyle changes and medical therapy in slowing the growth of small abdominal aortic aneurysms Promene načina života i medikamentna terapija u usporavanju rasta malih aneurizmi abdominalne aorte http://creativecommons.org/licenses/by/4.0/legalcode Podatak o licenci prema https://scindeks.ceon.rs/journaldetails.aspx?issn=0301-0619 Key words: abdominal aortic aneurysm, medical therapy, lifestyle changes, growth Ključne reči: aneurizma abdominalne aorte, medikamentna terapija, način života, rast info:eu-repo/semantics/article SUMMARY: The goal of our review was to evaluate the impact of lifestyle changes and medical therapy in slowing the growth of small abdominal aortic aneurysms (AAA), as well as to introduce current ideas for future treatment. No viable evidence was found that medical therapy can slow the growth of small AAAs. The beneficial role of propranolol, angiotensin-converting enzyme inhibitors and doxycycline in reducing the growth rate of AAA was ruled out by randomized controlled studies, whereas the efficiency of statins, macrolides and anti-platelet therapy remains controversial. On the other hand, smoking cessation is the only established lifestyle change that was effective in impeding the AAA expansion. Also, there are a considerable number of novel therapeutic strategies related to the problem, which still need to be evaluated in clinical trials, including administration of Cyclosporine A, gene therapy and mesenchymal stem cell treatment. SAŽETAK: Cilj našeg rada je bio da ispitamo uticaj promena načina života i medikamentne terapije na usporavanje rasta aneurizmi abdominalne aorte (AAA) i da ukažemo na aktuelne ideje za budući tretman. Nismo pronašli zadovoljavajuće dokaze da medikamentna terapije može da uspori rast malih AAA. Randomizovane kontrolisane studije su opovrgle povoljnu uloga propranolola, inhibitora angiotenzin-konvertujućeg enzima i doksiciklina u smanjenju rasta AAA, dok je efikasnost statina, makrolida i anti-trombocitnih lekova i dalje sporna. Sa druge strane, prestanak pušenja je jedina promena u načinu života koja se pokazala efikasnom u usporavanju rasta AAA. Takodje, značajnom broju novih terapeutskih strategija za usporavanje rasta AAA predstoje klinička ispitivanja, uključujući primenu ciklosporina A, genetsku terapiju i lokalnu primenu mezenhimalnih matičnih ćelija. https://unilib.phaidrabg.rs/o:2952 cobiss:126148361 ISSN: 0301-0619 application/pdf 96442 bytes eng 2016