o:2917 Cyanoacrylate embolization: a novelty in the field of varicose veins surgery en In the past 2 decades, varicose veins surgery went through a great turbulence and various innovations. A number of new techniques have been introduced with a goal to increase the success rate, reduce the periprocedural complications and, overall, to improve patients’ quality of life. The latest of them, named cyanoacrylate embolization (CAE) technique, threatens to shake the glory of the currently well-established endovenous methods. We have analyzed all previous studies by searching MEDLINE base using PubMed. Although the idea of using n-butyl cyanoacrylate (NBCA) glue in medical purposes was not new, the very first in vivo and animal experiments using NBCA for vein closure were conducted just at the beginning of this millennium. The results of these studies gave warranty to begin with the first interventions in humans. Early studies reported very high success rates of more than 90%, with the longest follow-up period of 36 months. There were no major adverse events reported, while the minor onesdmostly phlebitic reactionsdwere defined as mild to moderate. The newest head-to-head studies showed that CAE is a noninferior technique to other endovenous methods, with higher occlusion rates and fewer adverse events. Short procedure time and no need for tumescent anesthesia or compressive stockings reduce patients’ discomfort to the minimum and definitely seem to be a step forward answering the modern ‘‘walk inewalk out surgery’’ demands. As an easily handling technique, CAE undoubtedly pierces its path to the top of varicose veins surgery but more head-to-head clinical trials with longer follow-up periods are necessary to obtain a plain picture. Accepted version Key words: varicose veins surgery, cyanoacrylate embolization 91552100 125383433 1552101 0890-5096 1552099 10.1016/j.avsg.2018.06.009 2023-10-06T18:14:35.126Z 44 yes 46 Đorđe Radak 12465767 0000-0003-3199-5613 2019 46 Nenad Đukić 29990247 2019 46 Mihailo Nešković 29988455 0000-0003-4829-985X 2019 application/pdf 403486 https://unilib.phaidrabg.rs/o:2917 no yes 18 Podatak o licenci preuzet sa https://v2.sherpa.ac.uk/id/publication/10584 70 616.14‑007.64-089 92000002 71A11 Annals of Vascular Surgery 55 285 291 2019