o:2864 Heart failure in COVID-19 en AIMS: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. METHODS AND RESULTS: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62–81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44–2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01–2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24–4.29], P < 0.001). CONCLUSIONS: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality. Key words: COVID-19, SARS-CoV2, heart failure, cardiovascular disease, risk factors 91552100 125644809 1552101 1941-3289 1552099 10.1002/ehf2.13549 2023-09-29T11:10:50.828Z 44 yes 46 Mateusz Sokolski 105018377 2021 46 Peter P. Rainer 46 Markus Wallner 46 Alessandra Chiodini 46 Pascal S. Heiniger 46 Fran Mikulicic 46 Judith Schwaiger 46 Stephan Winnik 46 Huseyin A. Cakmak 46 Margherita Gaudenzi 46 Massimo Mapelli 46 Irene Mattavelli 46 Matthias Paul 46 Irina Cabac-Pogorevici 46 Claire Bouleti 46 Marzia Lilliu 46 Chiara Minoia 46 Jeroen Dauw 46 Jerome Costa 46 Ahmet Celik 46 Nathan Mawton 46 Carlos E.L. Montenegro 46 Yaya Matsue 46 Goran Lončar 29116519 0000-0001-8553-683X 46 Michal Marchel 46 Aris Bechlioulis 46 Lampros Michalis 46 Marcus Dorr 46 Edgard Prihadi 46 Felix Schoenrath 46 Daniel R. Messroghli 46 Wilfried Mullens 46 Lars H. Lund 46 Giuseppe M.C. Rosano 46 Piotr Ponikowski 46 Frank Ruschitzka 46 Andreas J. Flammer 46 Viktoria Muster 46 Klemens Ablasser 46 Gianfranco Sinagra 46 Davide Stolfo 46 Anne-Catherine Pouleur 46 Kristoffer G. Skaarup 46 Eduardo Barge-Caballero 46 Mats C. Hojbjerg Lassen 46 Tor Biering-Sorensen 46 Nana K. Poku 46 Philippe Meyer 46 Domenico D'Amario 46 Justyna M. Sokolska 46 Sander Trenson application/pdf 2518506 https://unilib.phaidrabg.rs/o:2864 no yes 18 70 616.1:616.9 92000001 71A11 ESC heart failure 8 6 4955 4967 2021