2015 Babić, Srđan Nešković, Mihailo Tanasković, Slobodan Sagić, Dragan Antonić, Želimir Popov, Petar Unić Stojanović, Dragana Gajin, Predrag Matić, Predrag Radak, Đorđe Medicinska istraživanja 49(3) info:eu-repo/semantics/article Benefits and risks of endovascular treatment in patients with proximal vertebral artery stenosis eng application/pdf 115950 bytes http://creativecommons.org/licenses/by/4.0/legalcode Podatak o licenci preuzet sa https://scindeks.ceon.rs/JournalDetails.aspx?issn=0301-0619 SUMMARY: Extracranial vertebral artery stenosis is an important cause of posterior circulation ischemic stroke. There are several therapeutic approaches in patients with vertebral artery (VA) stenosis, including medical, endovascular and surgical treatment. This review should summarize the literature concerning endovascular treatment (EVT) of extracranial VA stenosis. By scanning reference lists of other review articles and by searching electronic database MEDLINE by using major MESH term „vertebrobasilar insufficiency/therapy“ from January 2010 to April 2015, studies that included patients of any race, age and sex with symptomatic or asymptomatic atherosclerotic stenotic VA disease were identified. Periprocedural transitory ischemic attack (TIA) and stroke, and death within 30 days of the treatment were our primary interest and symptom resolution was secondary outcome measure. We found 12 retrospective studies with prospectively collected data and one additional comparative study of VA angioplasty/stenting and medical treatment was found. Percutaneous luminal angioplasty or stenting alone, or their combinations were performed in 693 patients (726 lesions). Periprocedural TIA or stroke occurred in 14 out of 693 patients (2.0%) and 30 days mortality in 1 (0.15%). A wide range of restenosis rates (3-58%) was reported. The literature shows that EVT of extracranial VA stenosis is safe and efficient. The vast majority of patients remain symptom free after the procedure, despite the restenosis rate. SAŽETAK: Ekstrakranijalna stenoza vertebralnih arterija je značajan uzrok ishemijskog moždanog udara u predelu zadnjeg sliva. Postoji više izbora mogućnosti lečenja, uključujući medikamentni, endovaskularni i hirurški pristup. Analizirana je literatura o endovaskularnom lečenju ekstrakranijalne stenoze vertebralnih arterija sa akcentom na indikacijama i preproceduralnim simptomima. Uvidom u radove i pretragom elektronske baze podataka MEDLINE koristeći MESH izraz „vertebrobasilar insufficiency/therapy“ u periodu od januara 2010 do aprila 2015 godine, identifikovane su studije sa stenozom vertebalnih arterija. Pronađeno je 12 studija sa prospektivno sakupljenim podacima i jedna komparativna studija koja poredi endovaskularni i medikamentni tretman. Nije bilo studija koje porede endovaskularni sa hirurškim pristupom. Endovaskularni tretman je urađen u 693 pacijenata (726 lezija). Periproceduralni TIA ili moždani udar javio se u 14 od 693 pacijenata (2,0%), sa 30-to dnevnim mortalitetom od 0.15%. Prijavljeni su različiti podaci o učestalosti restenoze (3-58%). Literatura je pokazala da je endovaskularni tretman ekstrakranijalne stenoze vertebralnih arterija bezbedna i efikasna procedura.Veći deo pacijenata nije imao ponavljanje simptome posle lečenja, nezavisno od učestalosti restenoze. https://unilib.phaidrabg.rs/o:2824 doi:10.5937/MedIst1503038B cobiss:125454857 ISSN: 0301-0619