o:2726 Comprehensive combined chemical and pharmacognostic approach in the investigation of Montenegrin flora, with emphasis on endemic species: Past performance and future potential en Herein, we have reviewed the comparative analysis relating pharmacognostic and chemical approaches in the investigation of the chosen plants from Montenegrin flora known for the constituents recognized as carriers of different biological activities. In addition, some of the mentioned extensively studied plants were with uncertain status in the systematics, as not being recognized as new species. The results of pharmacognostic studies with the thorough chemical analyses addressing the problem in positioning some of the investigated plants from Swertia, Gentiana and Gentianella genera belonging to family Gentianaceae in systematics, performed within the collaboration of two research groups from Institute for Medicinal Plants Research “Dr. Josif Panˇci´c” and Faculty of Chemistry, the University of Belgrade under the leadership of Dr. Nebojša Menkovi´c and Prof. Dr. Slobodan Milosavljevi´c were summarized. In addition, the complete chemical structure elucidation of sesquiterpene lactones present in Anthemis sp. as potential anti-inflammatory agents, applying the sophisticated 2D NMR techniques was reviewed. Further, the parthenolide content determination in Tanacetum larvatum revealed the possibility of the successful application of 1H NMR techniques in quantification studies. The findings presented in the published literature stressed the importance of a combined chemical and pharmacognostic approach in the investigation of natural products originating from plants Combined pharmacognostic and chemical research; Swertia, Gentiana, Gentianella, Anthemis and Tanacetum species; oxygenated xanthones; sesquiterpene lactones, taxonomic markers; structure-activity investigation of secondary metabolites 1552099 10.5937/leksir2141106M 1552101 0455-6224 2023-09-01T08:32:29.690Z 44 no 46 Nebojša Menković 46 Vanja Tadić Institut za proučavanje lekovitog bilja "Dr Josif Pančić" 0000-0003-1761-604X application/pdf 8385083 https://unilib.phaidrabg.rs/o:2726 no yes 1 70 92000002 71A10 Natural Medicinal Materials - Lekovite sirovine 41 106 125 2021