o:2595 Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression en Depression is a condition characterized by low mood and an aversion to activity, that causes behavioral problems, poor quality of life and limits daily life activities. It is considered as the fourth leading cause of disability worldwide. Selective Serotonin Reuptake Inhibitors (SSRIs) Monoamine Oxidase (MAO) inhibitors, Tricyclic Antidepressants (TCAs), and atypical antidepressants are some of the conventional medications used to treat depression. However, only about half of patients with major depressive disorder (MDD) respond effectively to first-line antidepressant therapy. Additionally, there are a number of drawbacks to standard antidepressants, such as anti-cholinergic side effects, drug-drug interactions, and food-drug interactions, which prompts researchers to look at alternative approaches to the treatment of depression. Medicinal plants and their metabolites are extensively tested for their efficacy against depression. Electronic databases such as Google scholar, Science Direct, SciFinder and PubMed were used to search relevant literature on the role of polyphenols in depression. Plants-derived Polyphenols represent a major class of compounds extensively distributed in plants. Number of polyphenols have demonstrated antidepressant activity, among which berberine, piperine, curcumin, naringenin, ascorbic acid and ginsenosides are extensively evaluated. The medicinal plants and their derived compounds mediated synthesized green nanoparticles have also exhibited considerable efficacy in the management of depression. The therapeutic effects of these phytochemicals is mediated via differentiation and inhibition of neuronal cell apoptosis, promotion of neuronal cell survival and modulation of key neurotransmitters. The aim of this study is to review compressively the chemical, pharmacological and neurological evidence showing the potential of polyphenols in depression. 1552099 10.3389/fphar.2022.1046599 1552101 1663-9812 2023-07-27T10:16:52.113Z 44 yes 46 Atul Kabra University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India Rushika Garg University School of Pharmaceutical Sciences, Rayat Bhara University, Mohali, Punjab, India person James Brimson Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok, Thailand person Jelena Živković Department for Pharmaceutical Research and Development, Institute for Medicinal Plants Research “Dr. Josif Pančić”, Belgrade, Serbia person 0000-0002-9684-2637 Saud Almawash Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia person Muhammad Ayaz Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan person Asif Nawaz Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan person Syed Shams Ul Hassan Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China ; Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China person Simona Bungau Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania person application/pdf 1704816 https://unilib.phaidrabg.rs/o:2595 no yes 16 70 92000002 71A10 Frontiers in Pharmacology 13 2022