
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/">
  <dc:format>application/pdf</dc:format>
  <dc:format>747431 bytes</dc:format>
  <dc:language>eng</dc:language>
  <dc:source>Nutrients 13(4550)</dc:source>
  <dc:description xml:lang="eng">The present study was conducted to estimate the exposure and characterize the risk for
the child population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of
3404 samples comprising milk and different milk-based food samples were collected from various
regions of Serbia from 2017 to 2019. Evaluation of AFM1 exposure was carried out using the
deterministic method, whereas risk characterization was evaluated using the margin of exposure

(MOE) and the risk of hepatocellular carcinoma (HCC). Detection rates for AFM1 in milk and milk-
based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level

(22.34 ± 0.018 ng kg−1

) of AFM1 being detected in pasteurized and UHT milk. According to the
three consumption estimates, the values of estimated daily intake (EDI) were higher for toddlers as
compared with children aged 3–9 years. Children aged 1–3 years had the highest risk of exposure
to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg−1 bw day−1 using lower
bound (LB) and upper bound (UB) exposure scenarios, respectively. Such difference could result from
the higher consumption to weight in younger children. Based on the estimated daily intake (EDI)
found in this study, the risk of AFM1 exposure due to consumption of milk and milk-based food
was low since the MOE values obtained were &gt;10,000. In addition, the risk of HCC cases/year/105
individuals of different age groups showed that the value of HCC, using potency estimates of
0.0017 (mean), was maximum (0.00034) in the age group 1–3 years, which indicates no health risk
for the evaluated groups. The present study revealed the importance of controlling and preventing
AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the
risk of AFM1 exposure, especially in children.</dc:description>
  <dc:date>2021</dc:date>
  <dc:identifier>https://unilib.phaidrabg.rs/o:165</dc:identifier>
  <dc:identifier>doi:10.3390/nu13124450</dc:identifier>
  <dc:title xml:lang="eng">Dietary exposure and risk assessment of Aflatoxin m1 for children aged 1 to 9 years old in Serbia</dc:title>
  <dc:creator id="https://orcid.org/0000-0003-0405-5896">Milićević, Dragan R.</dc:creator>
  <dc:creator>Milešević, Jelena</dc:creator>
  <dc:creator>Gurinović, Mirjana</dc:creator>
  <dc:creator id="https://orcid.org/0000-0002-5223-6993">Janković, Saša</dc:creator>
  <dc:creator id="https://orcid.org/0000-0003-4602-0835">Đinović-Stojanović, Jasna</dc:creator>
  <dc:creator>Zeković, Milica</dc:creator>
  <dc:creator>Glibetić, Marija</dc:creator>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
</oai_dc:dc>
