o:1471 New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies en Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H, and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/vis and FTIR), as well as TG and DTA. The analytical data of the complexes show the formation of mononuclear complexes with general formula [Cu(L)cyc](ClO4)2∙nH2O, (A): L = glycine, n = 1.5 and (B): L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The sixcoordinate octahedral geometry around Cu(II) in both complexes was proposed. TG-DTA analysis indicates that complex B decomposes exothermally in a single step in the range of 310 -400°C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocarcinoma cell line (HeLa), human melanoma (FemX) and human colon carcinoma (LS174). The IC50 values for the Cu(II) complexes were from 48.35-82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans. copper(II) complexes, cyclam, glycine, alanine, antimicrobial and cytotoxic activity 1552099 10.2298/JSC211107026D 1552101 0352-5139 2023-03-29T07:40:48.784Z 44 yes 46 Branka Dražić Faculty of Pharmacy - Belgrade New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies 0000-0003-1723-3268 Mirjana Antonijević-Nikolić Academy of Applied Studies Šabac, Department for Medical, Business and Technological Studies New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies person 0000-0003-4277-9780 Vukosava Živković-Radovanović Faculty of Chemistry, University of Belgrade New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies person 0000-0003-2558-4957 Branka Borović Institute of Meat Hygiene and Technology New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies person 0000-0003-0371-0991 Slađana B. Tanasković Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies person 0000-0002-3486-2800 Milena Marinović-Cincović Institute of Nuclear Sciences Vinča New copper(II) cyclam complexes with aminocarboxylate co- ligands: synthesis, characterization, and in vitro antiproliferative and antibacterial studies person 0000-0001-6197-1511 2022 application/pdf 1331663 https://unilib.phaidrabg.rs/o:1471 no yes 18 70 1552253 2022 71A01 Journal of the Serbian Chemical Society 451-464 87 4 451 464 Karnegijeva 4/III, P. O. Box 36, 1120 Belgrade 35, Serbia Serbian Chemical Society 2022